In general, a AAA ATPase acts in four stages - substrate recruitment, polypeptide initiation, polypeptide unfolding, and substrate release. Based on their substrate spectra, AAA ATPases can also be divided into three categories – promiscuous type, specific type, and orphan type. Zhejian's previous work has focused on the p97/Cdc48 ATPase, a typical promiscuous-type ATPase, and has uncovered its cryo-EM structures and molecular mechanism when processing a polyubiquitinated protein substrate. Building on this momentum, our lab will employ a combination of biochemistry, structural biology, and cell biology approaches to understand the critical functions of specific- and orphan-type ATPases in cell. Specific directions include:
季哲剑教授课题组
蛋白质复合物科学技术
Abstract
创建: Dec 02, 2022 | 15:50