# Assembly of nuclear pore complex - 季哲剑教授课题组

Nuclear pore complex is a protein mega-complex on nuclear envelope, controlling the transport of macromolecules into and out from the nucleus. Although recent structural studies have largely advanced our understanding on the architecture of nuclear pore complex, it remains unclear how this mega-complex is assembled in cell. Notably, the nuclear pore complex undergoes cell cycle-dependent dissolution and re-assembly during cell division, just like the nuclear envelope. An orphan-type ATPase – Torsin – has been implicated in the nuclear pore complex assembly. But little is known about the underlying mechanism. Furthermore, mutations in the human Torsin gene can lead to dystonia, a neuromuscular disorder. Our lab is interested in unraveling the function of Torsin in both dividing cells and non-dividing neuron cells.